WESCO Industries began service as West Central Iowa Workshop in 1966 when an initial feasibility study meeting was held in the local community. The study group determined in late 1966 that the entity would serve the seven-county region of Crawford, Audubon, Carroll, Ida, Monona, Shelby, and Harrison Counties. The town of Denison in Crawford County was selected as the home site, and the Articles of Incorporation were signed and registered in September of 1966, staff was hired, and services began with two individuals in June of 1968 and expanded to 14 individuals by November of 1968.

In December of 1979, plans were announced to build the present facility, and construction was finished by October of 1981 with approximately 65 individuals being served. Plans to accommodate up to 100 individuals were also put in place for future expansion.